Wölfe R, et al. Virological assessment of hospitalized patients with COVID-2019. Nature (2020). https://doi.org/10.1038/s41586-020-2196-x.
This is an accelerated article preview on a peer-reviewed paper that has been accepted for publication on Nature.
Here are some of the key points of the article:
1. Despite all patients only experience mild symptoms, all swabs from all patients taken between days 1 and 5 tested positive.
2. Pharyngeal virus shedding was very high during the first week of symptoms (peak at 7.11 × 108 RNA copies per throat swab, day 4). Infectious virus was readily isolated from throat- and lung-derived samples, but not from stool samples, in spite of high virus RNA concentration. Blood and urine never yielded virus.
Getting in close contact with the respiratory droplet of an infected person is the most likely way to get infected.
3. Peak concentrations of the virus were reached before day 5.
Patients with mild or no symptoms have the ability to infect others
4. The concentration of the virus decrease with time but can still be tested after 3 weeks.
5. The starting of seroconversion does not mean the COVID-2019 is completely gone; it only increase the rate of eliminating virus.
6. Whereas virus was readily isolated during the first week of symptoms from a considerable fraction of samples (16.66% in swabs, 83.33% in sputum samples), no isolates were obtained from samples taken after day 8 in spite of ongoing high viral loads.
7. Graph d shows that there is 50% chance of testing antibody from the 5th day after showing symptom. On day 9-10th, the infectivity of the patient becomes relatively low, nearly zero, which is also shown in graph f.
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